Chimeric Biocatalyst Combining Peptidic and Nucleic Acid Components Overcomes the Performance and Limitations of the Native Horseradish Peroxidase

Xiaobo Zhang, Dehui Qiu, Jielin Chen, Yue Zhang, Jiawei Wang, Desheng Chen, Yuan Liu, Mingpan Cheng, David Monchaud, Jean-Louis Mergny, Huangxian Ju, Jun Zhou

Journal of the American Chemical Society. 2023, 145, 8, 4517-4626

DOI: 10.1021/jacs.2c11318  ISSN : 0002-7863

Quadruplexes Are Everywhere…On the Other Strand Too: The i-Motif

Jean-Louis Mergny, Mingpan Cheng & Jun Zhou

N. Sugimoto (ed.), Handbook of Chemical Biology of Nucleic Acids

DOI: 10.1007/978-981-16-1313-5_5-1

A Double Hemin Bonded G-Quadruplex Embedded in Metal-Organic Frameworks for Biomimetic Cascade Reaction

Xuanxiang Mao, Dehui Qiu, Shijiong Wei, Xiaobo Zhang, Jianping Lei, Jean-Louis Mergny, Huangxian Ju, Jun Zhou

ACS Appl. Mater. Interfaces 14(49):54598-54606 (2022) 

DOI: 10.1021/acsami.2c18473  ISSN : 1944-8244

Efficient Biocatalytic System for Biosensing by Combining Metal–Organic Framework (MOF)-Based Nanozymes and G-Quadruplex (G4)-DNAzymes

Xuanxiang Mao, Fangni He, Dehui Qiu, Shijiong Wei, Rengan Luo, Yun Chen, Xiaobo Zhang, Jianping Lei, David Monchaud, Jean-Louis Mergny, Huangxian Ju, and Jun Zhou

Anal. Chem. 94(20): 7295-7302 (2022) 

DOI:10.1021/acs.analchem.2c00600   ISSN: 0003-2700

Highly Sensitive Biosensing Applications of a Magnetically Immobilisable Covalent G-Quadruplex-Hemin DNAzyme Catalytic System

Yun Chen, Dehui Qiu, Xiaobo Zhang, Yuan Liu, Mingpan Cheng, Jianping Lei, Jean-Louis Mergny, Huangxian Ju, Jun Zhou

Anal. Chem. 94(4): 2212-2219 (2022)

DOI:10.1021/acs.analchem.1c04842   ISSN: 0003-2700

The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms

Huang X, Zhao K, Jiang M, Qiu D, Zhou J, Yang Z.

J Biol Chem. 298(1): 101449 (2022)

DOI:10.1016/j.jbc.2021.101449    ISSN: 0021-9258

Exploring sequence space to design controllable G-quadruplex topology switches

Jielin Chen, Mingpan Cheng, Petr Stadlbauer, Jiří Šponer, Jean-Louis Mergny, Huangxian Ju, and Jun Zhou

CCS Chemistry. 4(9), 3036–3050 (2021) 
DOI: 10.31635/ccschem.021.202101357    ISSN: 2096-5745

The beginning and the end: flanking nucleotides induce a parallel G quadruplex topology

Jielin Chen, Mingpan Cheng, Gilmar F. Salgado^_, Petr Stadlbauer, Xiaobo Zhang, Samir Amrane, Aurore Guédin², Fangni He, Jiří Šponer, Huangxian Ju* , Jean-Louis Mergny* and Jun Zhou*

Nucleic Acids Research. 49(16): 9548-9559 (2021)
DOI: 10.1093/nar/gkab681    ISSN : 0305-1048

Drivers of i-DNA formation in a variety of environments revealed by four-dimensional UV melting and annealing

Mingpan Cheng*, Jielin Chen, Huangxian Ju, Jun Zhou*, Jean-Louis Mergny*

Journal of the American Chemical Society. (143)20: 7792–7807 (2021)
DOI: 10.1021/jacs.1c02209    ISSN : 0002-7863

Effects of sequence and base composition on the CD and TDS profiles of i-DNA.

Nunzia Iaccarino^#, Mingpan Cheng^#, Dehui Qiu, Bruno Pagano, Jussara Amato, Anna Di Porzio, Jun Zhou, Antonio Randazzo*, Jean‐Louis Mergny

Angewandte Chemie International Edition. 60(18): 10295-10303 (2021)
DOI: 10.1002/anie.202016822    ISSN : 1433-7581

Thermal and pH Stabilities of i‐DNA: Confronting in vitro Experiments with Models and In‐Cell NMR Data

Mingpan Cheng, Dehui Qiu, Liezel Tamon, Eva Ištvánková, Pavlína Víšková, Samir Amrane, Aurore Guédin, Jielin Chen, Laurent Lacroix, Huangxian Ju, Lukáš Trantírek, Aleksandr B. Sahakyan, Jun Zhou*, Jean‐Louis Mergny

Angewandte Chemie International Edition. 60(18): 10286-10294 (2021)
DOI: 10.1002/anie.202016801    ISSN : 1433-7581

Insights into G-Quadruplex–Hemin Dynamics Using Atomistic Simulations: Implications for Reactivity and Folding

Petr Stadlbauer*, Barira Islam, Michal Otyepka, Jielin Chen, David Monchaud, Jun Zhou, Jean-Louis Mergny, and Jiří Šponer*

Journal of Chemical Theory and Computation. 17(3): 1883-1899 (2021)
DOI: 10.1021/acs.jctc.0c01176    ISSN : 1549-9618

The catalytic properties of DNA G-quadruplexes rely on their structural integrity

Jielin Chen^#, Mingpan Cheng^#, Jiawei Wang, Dehui Qiu, David Monchaud, Jean-Louis Mergny, Huangxian Ju*, Jun Zhou*

Chinese Journal of Catalysis. 42(7): 1102-1107 (2021)
DOI: 10.1016/s1872-2067(20)63744-5    ISSN : 0253-9837

An oxidatively damaged G-quadruplex/hemin DNAzyme.

Jiawei Wang^#,Mingpan Cheng^#,Jielin Chen,Huangxian Ju,David Monchaud,Jean-Louis Mergny,Jun Zhou*

Chemical Communications. 56(12): 1839-1842 (2020)
DOI: 10.1039/c9cc09237d    ISSN : 1359-7345

A push–pull mechanism helps design highly competent G-quadruplex-DNA catalysts

Jielin Chen, Jiawei Wang, Stephanie C. C. van der Lubbe, Mingpan Cheng, Dehui Qiu, David Monchaud, Jean-Louis Mergny, Célia Fonseca Guerra*, Huangxian Ju* & Jun Zhou*

CCS Chemistry. 2, 2183-2193 (2020)
DOI: 10.31635/ccschem.020.202000473    ISSN: 2096-5745

Highly active G-quadruplex/hemin DNAzyme for sensitive colorimetric determination of lead(II).

Jielin Chen,Yingying Zhang,Mingpan Cheng,Jean-Louis Mergny,Qianmei Lin,Jun Zhou*,Huangxian Ju*

Mikrochim Acta. 186(12):786 (2019)
DOI: 10.1007/s00604-019-3950-3    ISNN : 0026-3672

Probing the interaction of coppercofactor and azachalcone substrate with G-quadruplex of DNA based Diels-Alderase by site-specific fluorescence quenching titration.

Mingpan Cheng^#, Jingya Hao^#, Yinghao Li, Yu Cheng, Guoqing Jia, Jun Zhou, Can Li*.

Biochimie. 146: 20-27 (2018)
DOI: 10.1016/j.biochi.2017.11.001     ISSN : 0300-9084

DNA quadruplexes as molecular scaffolds for controlled assembly of fluorogens with aggregation-induced emission,

Longyi Zhu, Jun Zhou, Guohua Xu, Conggang Li, Pinghua Ling, Bin Liu*, Huangxian Ju*, Jianping Lei*.

Chemical Science. 9(9): 2559-2566 (2018)
DOI: 10.1039/c8sc00001h    ISSN : 2041-6520

Loop permutation affects the topology and stability of G-quadruplexes.

Mingpan Cheng, Yu Cheng, Jingya Hao, Guoqing Jia, Jun Zhou, Jean-Louis Mergny,* and Can Li*

Nucleic Acids Research. 46(18): 9264-9275 (2018)
DOI: 10.1093/nar/gky757    ISSN : 0305-1048

Thermal denaturation profile: A straightforward signature to characterize parallel G-quadruplexes.

Yingying Zhang, Jielin Chen, Huangxian Ju*, Jun Zhou*

Biochimie. 157: 22-25 (2019)
DOI: 10.1016/j.biochi.2018.10.018    ISSN : 0300-9084

Single-sided competitive axial coordination of G-quadruplex/Hemin as molecular switch for Imaging Intracellular nitric oxide.

Lei Zhang^#, Jun Zhou^#, Fengjiao Ma, Quanbo Wang, Hui Xu*, Huangxian Ju*, Jianping Lei*

Chemistry. 25(2): 490-494 (2019)
DOI: 10.1002/chem.201804897    ISSN : 0947-6539

How proximal nucleobases regulate the catalytic activity of G-quadruplex/Hemin DNAzymes.

Jielin Chen, Yingying Zhang, Mingpan Cheng, Yuehua Guo, Jiri Šponer, David Monchaud, Jean-Louis Mergny, Huangxian Ju,* Jun Zhou*

ACS Catalysis. 8 (12): 11352-11361 (2018)
DOI: 10.1021/acscatal.8b03811    ISSN : 2155-5435

Relations between the loop transposition of DNA G-quadruplex and the catalytic function of DNAzyme.

Mingpan Cheng, Jun Zhou, Guoqing Jia, Xuanjun Ai, Jean-Louis Mergny, Can Li*

Biochimica et Biophysica Acta-General Subjects. 1861(8):1913-1920 (2017)
DOI: 10.1016/j.bbagen.2017.05.016    ISSN : 0304-4165

A thermophilic tetramolecular G-quadruplex/Hemin DNAzyme.

Yuehua Guo, Jielin Chen, Mingpan Cheng, David Monchaud, Jun Zhou*, Huangxian Ju*

Angewandte Chemie International Edition. 56(52): 16636-16640 (2017)
DOI: 10.1002/anie.201708964    ISSN : 1433-7581

Unexpected position dependent effects of ribose G-quartets in G-quadruplexes.

Jun Zhou*, Samir Amrane, Frédéric Rosu, Gilmar F. Salgado, Yunqiang Bian, Hisae Tateishi-Karimata, Eric Largy, Dursun Nizam Korkut, Anne Bourdoncle, Daisuke Miyoshi, Jian Zhang, Huangxian Ju, Wei Wang*, Naoki Sugimoto, Valérie Gabelica, Jean-Louis Mergny*

Journal of the American Chemical Society. 139(23): 7768-7779 (2017)
DOI: 10.1021/jacs.7b00648    ISSN : 0002-7863

The efect of adenine repeats on G-quadruplex/Hemin peroxidase mimicking DNAzyme activity.

Jielin Chen#, Yuehua Guo#, Jun Zhou*, Huangxian Ju*

Chemistry. 23(17): 4210-4215 (2017)
DOI: 10.1002/chem.201700040    ISSN : 0947-6539

Enantio selective sulfoxidation reaction catalyzed by a G-quadruplex DNA metallo enzyme

Mingpan Cheng, Yinghao Li, Jun Zhou, Guoqing Jia, Shengmei Lu, Yan Yang, Can Li*

Chem Commun (Camb). 52(62): 9644-9647 (2016)
DOI: 10.1039/c6cc03016e    ISSN : 1359-7345

Reevaluation of the stability of G-quadruplex structures under crowding conditions

Jun Zhou*, H. Tateishi-Karimata, Jean-Louis Mergny, Mingpan Cheng, Zhaochi Feng, Daisuke Miyoshi, Naoki Sugimoto, Can Li*

Biochimie. 121: 204-208 (2016)
DOI: 10.1016/j.biochi.2015.12.012    ISSN : 0300-9084

Assembly of chemically modified G-rich sequences intotetramolecular DNA G-quadruplexes and higher order structures

Zhou J, Rosu F, Amrane S, Korkut DN, Gabelica V, Mergny JL.

Methods. 2014, 67, 159–168.
DOI: 10.1016/j.ymeth.2014.01.004    ISSN : 1046-2023

Effects of six-membered carbohydraterings on structure, stability and kinetics of G-quadruplexes.

Zhou J, Abramov M, Liu F, Amrane S, Bourdoncle A, Herdewijn P, Mergny JL.

Chem. Eur. J. 2013, 19,14719–14725.
DOI:10.1002/chem.201301743    ISSN : 0947-6539

The “sugar-deficient” G-quadruplex: incorporation of aTNA in quadruplex structures.

Zhou J，Murayama K, Amrane S, Rosu F, Kashida H, Bourdoncle A, Asanuma H, Mergny JL.

Chem. Sci. 2013, 4, 3693–3698.
DOI: 10.1039/c3sc50474c    ISSN : 2041-6520

Combining i-motif and G-quadruplexes within the same strand: formation and application.

Zhou J, Amrane S, Korkut DN, Bourdoncle A, He HZ, Ma DL, MergnyJL.

Angew. Chem. Int. Ed. 2013, 52, 7742–7746.
DOI: 10.1002/anie.201301278    ISSN : 1433-7851

Tri-G-quadruplex: Controlled assembly of a G-quadruplex structure from three G-rich strands.

Zhou J, Bourdoncle A, Rosu F, Gabelica V, Mergny JL.

Angew. Chem. Int. Ed. 2012, 51, 11002–11005.
DOI: 10.1002/ange.201205390    ISSN : 1433-7581

Formation and stabilization of G-quadruplex in nanosized water pool

Zhou J, Wei C, Jia G, Wang X, Feng Z, Li C.

Chem. Comm. 2010, 46, 1700–1702.
DOI: 10.1039/b925000j    ISNN : 1359-7345

Properties ofi-motif under molecular crowding conditions

Zhou J, Jia G, Feng Z, Li C.

Chin. J. Chem. U.  2010, 31, 309–311.
DOI:10.1016/S1872-2040(09)60019-0    ISSN : 0253-3820

Formation of i-motif structure at neutral and slightly alkaline pH

Zhou J, Wei C, Jia G, Wang X, Feng Z, Li C.

Mol. Biosyst. 2010, 6, 580–586.
DOI: 10.1039/b919600e    ISSN : 1742-206X

Human telomeric G-quadruplex formed from duplex undernear physiological conditions: spectroscopic evidence and kinetics

Zhou J, Wei C, Jia G, Wang X, Feng Z, Li C.

Biochimie. 2009, 91, 1104–1111.
DOI: 10.1016/j.biochi.2009.05.014    ISSN : 0300-9084

The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions.

Zhou J, Wei C, Jia G, Wang X, Tang Q, Feng Z, Li C.

Biophys. Chem. 2008, 136, 124–127.
DOI: 10.1016/j.bpc.2008.05.005    ISSN : 0301-4622